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学术报告

报告题目：Mechanistic study of snRNP biogenesis and pathogenesis of spinal muscular atrophy

报告人：Rundong (Ray) Zhang, Ph.D.

        Research Associate

        Howard Hughes Medical Institute,

        University of Pennsylvania School of Medicine

时间：2014年4月30日(星期三)下午2:00

地点：生化三层中厅

主持人：尹玉新教授

 

Abstract:

Dr. Zhang is research associate at Dr. Gideon Dreyfuss’s (member of National Academy of Sciences and member of American Academy of Arts and Sciences) lab in Howard Hughes Medical Institute, University of Pennsylvania School of Medicine. Dr. Zhang graduated from Beijing Medical University in 1995. He received PhD at University of Louisville in 2006. He did postdoctoral training with Dr. Stephen Sprang at University of Texas Southwestern Medical Center. Dr. Zhang’s current research interest focused on the SMN complex, which is a key factor in the disease of spinal muscular atrophy. He identified how the 9-component SMN complex assembles an 8-component snRNP core complex. This work was published in Cell and was cited as a breakthrough in the field. Skilled in biochemistry and crystallography, Dr. Zhang continues to shed light on important basic biological principles which underlie snRNP biogenesis and pathogenesis of spinal muscular atrophy.

Representative Publication:

1. Rundong Zhang, Byung Ran So, Pilong Li, Jeongsik Yong, Tina Glisovic, Lili Wan, and Gideon Dreyfuss, Structure of a key intermediate of the SMN complex reveals Gemin2's crucial function in snRNP assembly. (2011) Cell, Aug; 146(3): 384-95.

2. Rundong Zhang, Tae-Kang Kim, Zhuan-Hong Qiao, Jian Cai, William M. Pierce Jr., and Zhao-Hui Song, Biochemical and mass spectrometric characterization of human CB2 cannabinoid receptor expressed in Pichia pastoris—importance of correct processing of the N-terminus. (2007)  Protein Expr Purif. Oct; 55(2): 225-35. Epub 2007 Apr 7.