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报告题目： Intracellular degradation by autophagy ---- the molecular mechanism and physiological role 自噬导致的细胞内物质降解的分子机制和生理学研究   报告人：   Professor Noboru Mizushima    Department of Physiology and Cell Biology, Tokyo Medical and Dental University 日本 东京医科齿科大学 生理和细胞生物学系 时　间：  2008 年10月7日 ( 周二) 上午10：00-11：30 主持人：  朱卫国 教授（北京大学基础医学部生物化学与分子生物学系） 地　点：  北京大学医学部会议中心20 6 室                                                                    北京大学基础医学部

                                                                                                           2008年9月25日

报告人简介： Noboru Mizushima（MD，PHD）,  Professor of Department of Physiology and Cell Biology at Tokyo Medical and Dental University, has devoted his career to use of molecular approaches to study Autophagy and related basic biological questions.   Awards: 2001      Young investigator award of the Japanese Biochemical Society 2005   Mitsubishi Chemical Award of the Molecular Biology Society of Japan 2006      The Commendation for Science and Technology by the Minister of                      Education, Culture, Sports, Science and Technology, The Young Scientists’ Prize 2007     FEBS Letters Young Scientist Award 2008     JSPS (Japan Society for the Promotion of Science) Prize 2008     Brain Science Foundation, Tsukahara Award   Publication list (selected) 1.          Nedjic, J., Aichinger, M., Emmerich, J., Mizushima, N., Klein, L. Macroautophagy in thymic epithelial cells shapes the T cell repertoire and is essential for self-tolerance. Nature (2008) in press 2.          Tsukamoto, S., Kuma, A., Murakami, M., Kishi, C., Yamamoto, A., Mizushima, N.  Autophagy is essential for preimplantation development of mouse embryos. Science 321: 117-120 (2008) 3.          Mizushima, N., Levine, B., Cuervo, A.M., Klionsky, D.J. Autophagy fights disease through cellular self-digestion Nature 451:1069-1075 (2008) 4.          Nakai, A., Yamaguchi, O., Takeda, T., Higuchi, Y., Hikoso, S., Taniike, M., Omiya, S., Mizote, I., Matsumura, Y., Asahi, M., Nishida, K., Hori, M., Mizushima, N., Otsu, K.  The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress. Nat. Med. 13:619-24 (2007) 5.          Lee, H.K., Lund, J.M., Ramanathan, B., Mizushima, N., Iwasaki, A. Autophagy-dependent viral recognition by plasmacytoid dendritic cell. Science 315: 1398-1401 (2007) 6.          Hara, T., Nakamura, K., Matsui, M., Yamamoto, A., Nakahara, Y., Suzuki-Migishima, R. Yokoyama, M., Mishima, K., Saito, I., Okano, H., Mizushima, N.  Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature 441, 885-889 (2006). 7.          Ogawa, M., Yoshimori, T., Suzuki, T., Sagara, H., Mizushima, N., Sasakawa, C. Escape of intracellular Shigella from autophagy. Science 307, 727-731 (2005) 8.          Pattingre, S., Tassa, A., Qu, X., Garuti, R., Huan Liang, X., Mizushima, N., Packer, M., Schneider, M.D., Levine, B. Bcl-2 Antiapoptotic Proteins Inhibit Beclin 1-Dependent Autophagy. Cell 122, 927-939 (2005). 9.          Kuma, A., Hatano, M., Matsui, M., Yamamoto, A., Nakaya, H., Yoshimori, T., Ohsumi, Y., Tokuhisa, T., Mizushima, N.  The role of autophagy during the early neonatal starvation period. Nature. 432, 1032-1036 (2004). 10.     Nakagawa, I., Amano, A., Mizushima, N., Yamamoto, A., Yamaguchi, H., Kamimoto, T., Nara, A., Funao, J., Nakata, M., Tsuda, K., Hamada, S., Yoshimori, T. Autophagy defends cells against invading group A Streptococcus. Science. 306, 1037-1040 (2004). 11.     Ichimura, Y., Kirisako, T., Takao, T., Satomi, Y., Shimonishi, Y., Ishihara, N., Mizushima, N., Tanida, I., Kominami, E., Ohsumi, M., Noda, T. and Ohsumi, Y. A ubiquitin-like system mediates protein lipidation Nature 408, 488-492. (2000) 12.     Mizushima, N., Noda, T., Yoshimori, T., Tanaka, Y., Ishii, T., George, M. D., Klionsky, D. J., Ohsumi, M. and Ohsumi, Y. A protein conjugation system essential for autophagy Nature 395, 395-398. (1998)   记继续教育学分I类1分，欢迎踊跃参加！