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报告题目：Epigenetic mechanisms of cellular heterogeneity

报 告 人：Keji Zhao，Ph.D.

                Senior Investigator, Laboratory of Epigenome Biology 

                Director of Systems Biology Center

                National Heart, Lung and Blood Institute, NIH

时      间：2019 年10 月15 日（星期二）上午10:00-11:00

地      点：生化楼三层中厅

主 持 人：钟超研究员

 

报告简介：

 Recent studies have revealed a substantial variation in gene expression across different single cells, even within a homogeneous population of cells. In order to understand the underlying mechanisms of the cellular variation, we have developed single-cell techniques, including scDNase-seq and scMNase-seq, to analyze the epigenomic profiles at a single-cell level. Application of these techniques to various cell types revealed unexpected rules of chromatin organization and provided insights into the epigenetic basis of cellular heterogeneity in gene expression.

 

 

REFERENCES

Wenfei Jin et al. (2015). Genome-wide Detection of DNase I Hypersensitive Sites of Single Cells and Formalin-fixed Patient Cells on Paraffin Slides. Nature, 528(7580):142-6. doi: 10.1038/nature15740. Binbin Lai et al., (2018). Principles of nucleosome organization revealed by single-cell MNase-seq. Nature, 562(7726):281-285. doi: 10.1038/s41586-018-0567-3. Epub 2018 Sep 26.

 

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