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　　报告题目： Modes of p53 regulation

　　报告人：Professor Wei Gu

　　The Institute of Cancer Genetics

　　Columbia University Medical Center, New York

　　时间：2010年 10月 15日(星期五) 下午2:00

　　地点： 医学部逸夫教学楼409

　　主持人：尹玉新教授

　　     报告人简介：

　　Dr. Wei Gu is Professor in the Department of Pathology and Cell Biology at Columbia University. He received his Ph.D. with honors from Columbia University in 1995 and then performed his post-doctoral research at Rockefeller University. Dr. Wei Gu joined Columbia University Medical Center as an Assistant Professor in 1999 and was promoted to tenured Associate Professor in 2004 and Full Professor in 2007. His research is focused on p53 in tumor suppression and aging. Dr. Gu made discovery that p53 is acetylated and that its tumor suppression activity is tightly regulated by both acetylation and deacetylation. Thus, Dr. Gu played the leading role in establishing p53 as the first non-histone substrate for histone acetyl-transferases and deacetylases. By introducing the notion that reversible acetylation is a general mechanism for regulation of non-histone proteins, the impact of this work was felt well beyond the p53 field. In addition, the Gu’s laboratory found that the HAUSP protein is a major regulator of the p53 pathway that specifically deubiquitinates, and thereby stabilizes, multiple pathway components, including Mdm2 and p53 itself. Again, these observations had important implications beyond p53 since, prior to this, the ubiquitin-proteasome pathway was thought to be a unidirectional process that inexorably lead to protein degradation. The Gu’s laboratory also found that monoubiquitination, but not other forms of ubiquitin conjugation, acts as a specific signal for nuclear export of p53. More recently, Dr. Gu’s group identified other key regulators of the p53 pathway, including the ARF-BP1 and DBC1 proteins.  Over the years, Dr. Gu has published a total of 75 peer-reviewed papers including 2 Science, 6 Nature, and 9 Cell papers.

Honors and Awards: 

　　On the basis of his scientific accomplishments, Dr. Gu has been awarded many prestigious honors, including the Irma Hirschl Trust Award, the Leukemia and Lymphoma Society Scholar Award, the Stohlman Scholar Award, and the Ellison Medical Foundation Senior Scholar Award.  Dr. Gu is the fellow of American Association for the Advancement of Science, American Society of Microbiology, American Society of Biochemistry & Molecular Biology, Ray Wu Society and Society of Chinese Biologists in America.