JDB电子官方网站庆祝北医百年庆典系列活动

JDB电子官方网站院长论坛系列十三

　　报告题目：Chromatin regulation and genome maintenance by mammalian Sirtuins

　　报告人：Katrin Faye Chua, MD., Ph.D.

　　Professor in Medicine, Division of Endocrinology, Gerontology and Metabolism,

　　Stanford University School of Medicine, Stanford, CA, USA

　　时间：2012年6月26日（星期二）上午10：00-11：00

　　地点：北京大学医学部生化楼三层中厅

　　主持人：朱卫国教授

　　报告人简介：

　　Education:

　　Harvard University, BA, 1991, Biochemistry,

　　Harvard Medical School, Ph.D., 2001, Cell Biology

　　Harvard Medical School, MD., 2001, Medicine

　　Harvard Medical School, Post-doc, 2005, Genetics/Immunology

　　The main focus of Dr. Chua’s laboratory is the function of mammalian Sirtuin (SIRT) deacetylase genes, and the intersection between the biology of aging, cancer and chromatin regulation. She is an excellent molecular biologist and published many milestone papers in Cell Nature and Science.

　　Selected publications:

　　Barber MF, Michishita-Kioi E, Xi Y, Young NL Chen K, strul K Gozani O, Li W and Chua KF.  SIRT7 links H3K18 deacetylation to maintainance of onncogenic transformation.  Nature, 2012, Online,June 2.

　　Tennen RI, Michishita-Kioi E, Chua KF. Finding a target for resveratrol.

　　Cell. 2012 Feb 3;148(3):387-9.

　　Kawahara TL, Michishita E, Adler AS, Damian M, Berber E, Lin M, McCord RA, Ongaigui KC, Boxer LD, Chang HY, Chua KF. SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span. Cell. 2009 Jan 9;136(1):62-74.

　　Michishita E, McCord RA, Berber E, Kioi M, Padilla-Nash H, Damian M, Cheung P, Kusumoto R, Kawahara TL, Barrett JC, Chang HY, Bohr VA, Ried T, Gozani O, Chua KF. SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin. Nature. 2008 Mar 27;452(7186):492-6.

　　Cheng HL, Mostoslavsky R, Saito S, Manis JP, Gu Y, Patel P, Bronson R, Appella E, Alt FW, Chua KF. Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):10794-9.