联系方式

　　电话：010-82802846-5032

　　Email: yw@bjmu.edu.cn

　　基本情况：

　　王应，女，博士学位。现任北京大学人类疾病基因研究中心，北京大学医学部免疫学系教授，博士生导师。

　　研究方向：

　　从人类基因组编码基因中发现潜在的新趋化因子，并进行表达、结构、功能和作用机制的研究，及其相关自主创新药物的研发。

　　主持科研项目：

　　2013.1-2016.12国家自然科学基金面上项目“从人类基因组编码基因中发现潜在的新趋化因子，并进行表达、功能、机制的研究”

　　2012.1-2016.8 973计划“重大心血管疾病相关GPCR新药物靶点的基础研究”（课题骨干）

　　2013.1-2015.12高等学校博士学科点专项科研基金“新趋化因子趋化作用机制的研究”

　　2011.1-2013.12国家自然科学基金面上项目“CMTM8及其变异体在肿瘤细胞上皮间质转化中的作用及机制研究”

　　2009.1-2010.12科技部“重大新药创制”科技重大专项“趋化素样因子1衍生多肽作为候选新药的研究与开发”

　　2009.1-2011.12国家自然科学基金重大研究计划培育项目“针对CKLF1与趋化因子受体的相互作用设计、发现和获取小分子化合物及其炎症干预作用的研究”

　　2009.1-2011.12国家自然科学基金面上项目“CKLF1趋化作用机制的研究”

　　2007.1-2009.12国家自然科学基金面上项目“CMTM8在细胞因子受体转运和信号转导中调控作用的研究”

　　2003.1-2005.12国家自然科学基金面上项目“人趋化素样因子相关蛋白2的结构与功能研究”

　　代表性论文(*代表通讯作者）：

　　Xiaolei Pei, Qianying Sun, Yan Zhang, Pingzhang Wang, XinjianPeng, Changyuan Guo, Enquan Xu, Yi Zheng, Xiaoning Mo, Jing Ma, Dixin Chen, Yang Zhang, Yingmei Zhang, Quansheng Song, Shuai Guo, Taiping Shi, Zhixin Zhang, Dalong Ma, Ying Wang*. PC3-secreted microprotein is a Novel Chemoattractant Protein and Functions as a High Affinity Ligand for CC Chemokine Receptor 2. J Immunol, 2014, 192:1878-86.

　　Wenjuan Zhang, Michelle Mendoza, Xiaolei Pei, Sarah Mahoney, Didem Ilter, Yingmei Zhang, Dalong Ma, John Blenis*, Ying Wang*. Down-regulation of CMTM8 induces EMT-like changes and cell motility through c-MET-ERK signaling. J Biol Chem, 2012, 287, 11850-8.

　　Linjie Tian, Wen Li, Jiaoli Wang, Yan Zhang, Yi Zheng, Hui Qi, Xiaohuan Guo, Yingmei Zhang, Dalong Ma, Huahao Shen*, Ying Wang*. The CKLF1-C19 peptide attenuates allergic lung inflammation by inhibiting CCR3- and CCR4- mediated chemotaxis in a mouse model of asthma. Allergy, 2011, 66: 287–297.

　　Yi Zheng, Changyuan Guo, Yan Zhang, Hui Qi, Qianying Sun, Enquan Xu, Yingmei Zhang, Dalong Ma, Ying Wang*. Alleviation of murine allergic rhinitis by C19, a C-terminal peptide of chemokine-like factor 1 (CKLF1). International Immunopharmacology, 2011, 11, 2188-2193.

　　Yan Zhang; Linjie Tian; Yi Zheng; Hui Qi; Changyuan Guo; Qianying Sun; Enquan Xu; Yingmei Zhang; Dalong Ma; Ying Wang*. C-terminal peptides of Chemokine-like factor 1 signal through chemokine receptor CCR4 to cross-desensitize the CXCR4. Biochemical and Biophysical Research Communications, 2011, 409: 356-361.

　　Ying Wang, Yingmei Zhang, Wenling Han, Dan Li, Linjie Tian, Caihua Yin, Dalong Ma*. Two C-terminal peptides of human CKLF1 interact with chemokine receptor CCR4. Int.J.Biochem.Cell.Biol. 2008, 40: 909-919.

　　Ying Wang, Yingmei Zhang, Xue Yang, Wenling Han, Yanan Liu, Qianmei Xu, Rui Zhao, Chunhui Di, Quansheng Song, Dalong Ma*. Chemokine-Like Factor 1 Is a Functional Ligand for CC Chemokine Receptor 4 (CCR4). Life Sciences, 2006, 78, 614-621.

　　Hui Qi, Yi Zheng, Enquan Xu, Changyuan Guo, Yan Zhang, Qianying Sun, Junhai Xiao, Dalong Ma, Ying Wang*. An antagonist for CCR4 alleviates murine allergic rhinitis by intranasal administration. International archives of allergy and immunology. 2012, 159, 297-305.

　　Dazhen Liu, Caihua Yin, Yingmei Zhang, Linjie Tian, Ting Li, Dan Li, Dalong Ma, Yinglu Guo, Ying Wang*. Human CMTM2/CKLFSF2 Enhances Androgen Receptor’s Transcriptional Activity. Chinese Science Bulletin, 2009, 54, 1050-1057.

　　Dan Li, Caining Jin, Bo Pang, Yingmei Zhang, Caihua Yin, Linjie Tian, Wenling Han, Dalong Ma, Ying Wang*. An alternative splice form of CMTM8 induces apoptosis. Int.J.Biochem.Cell.Bio. 2007, 39, 2107–2119.

　　Lin Shi, Quansheng Song, Yingmei Zhang, Yaxin Lou, Yanfang Wang, Linjie Tian, Yi Zheng, Dalong Ma, Xiaoyan Ke*and Ying Wang*. Potent antitumor activities of recombinant human PDCD5 protein in combination with chemotherapy drugs in K562 cells. Biochemical and Biophysical Research Communications, 2010, 396: 224–230.

　　Ying Wang, Dan Li, Hui Fan, Linjie Tian, Yingcheng Zhong, Yingmei Zhang, Lan Yuan, Caining Jin, Caihua Yin, Dalong Ma*. Cellular uptake of exogenous human PDCD5 protein. J Biol Chem, 2006, 281, 24803-24817.