韩盈副研究员

北京大学中国药物依赖性研究所副研究员  博士生导师

电话：13261995331或010-82802456

E-mail：yinghan@bjmu.edu.cn

简介

主要从事抑郁症的发病机制及干预研究，深入探索了情感记忆储存、去稳定化-再稳定化的动态更新过程，提出了快速抗抑郁治疗的新假说，并发现了靶向情感记忆、肠道菌群和神经免疫系统的新的干预策略。目前已发表SCI论文45篇，申请专利3项并获得授权1项；其中作为第一、共同第一/通讯作者发表SCI论文20篇，包括Molecular Psychiatry（5篇）、Neuroscience and Biobehavioral Reviews（1篇）、Neuropsychopharmacology（2篇）、The Journal of Neuroscience（1篇）和Translational Psychiatry（3篇）等期刊论文。担任中国心理学会生理心理专业委员会委员、中国毒理学会药物依赖性毒理学专业委员会青年委员和中国卒中学会脑健康分会青年委员。入选了第六届中国科协青年人才托举工程和北京市科协2021-2023年度青年人才托举工程。先后主持国家自然科学基金青年和面上项目、国家重点研发计划子课题和和国家脑计划青年项目子任务等10个项目。

研究方向

1.肠道菌群在抑郁症及其共病睡眠障碍中的作用及脑-肠轴机制

2.社会隔离应激导致精神行为异常的分子和神经环路机制

3.小胶质细胞-神经元相互作用在神经突触修剪和抑郁症发病中的机制

4.脑多靶点电刺激调控技术对抑郁症及共病睡眠障碍的疗效评价及其机制

5.病理性情感记忆储存和维持的神经机制

代表性论文论文（^＃共同第一作者，^＊共同通讯作者）

1. Wang Z^#, Chen WH^#, Li SX, He ZM, Zhu WL, Ji YB, Wang Z, Zhu XM, Yuan K, Bao YP, Shi L, Meng SQ, Xue YX, Xie W, Shi J, Yan W^*, Wei H^*, Lu L^*, Han Y^*. Gut microbiota modulates the inflammatory response and cognitive impairment induced by sleep deprivation.  Mol Psychiatry . 2021 May 7. (IF =" 15.992)

2. Han Y^#, Sun CY^#, Meng SQ^#, Tabarak S, Yuan K, Cao L, Yan W, Xu LZ, Deng JH, Zhu WL, Li JL, Lu L^*, Xue YX^*, Shi J^*. Systemic immunization with altered myelin basic protein peptide produces sustained antidepressant-like effects.  Mol Psychiatry , 2020 Jun;25(6):1260-1274  (IF = 15.992)  

3. Yu ZL^#, Han Y^#, Hu D^#, Chen N, Zhang ZY, Chen WX, Xue YX, Meng SQ, Lu L, Zhang W*, Shi J*. Neurocan regulates vulnerability to stress and the anti-depressant effect of ketamine in adolescent rats.  Mol Psychiatry . 2022 Mar 9. doi: 10.1038/s41380-022-01495-w.   (IF = 15.992)

4. Li SX^#, Han Y^#, Xu LZ^#, Yuan K, Zhang RX, Sun CY, Xu DF, Yuan M, Deng JH, Meng SQ, Gao XJ, Wen Q, Liu LJ, Zhu WL, Xue YX, Zhao M, Shi J, Lu L^*. Uncoupling DAPK1 from NMDA receptor GluN2B subunit exerts rapid antidepressant-like effects.  Mol Psychiatry . 2018 Mar;23(3):597-608. (IF = 15.992)

5. Yan W^#, Liu JF^#, Han Y^#, Zhang W, Luo YX, Xue YX, Zhu WL, Yang C, Chen WH, Guo HL, Ma YN, Yuan K, Wang JS, Shi J, Lu L^*. Protein kinase Mζ in medial prefrontal cortex mediates depressive-like behavior and antidepressant response.  Mol Psychiatry . 2018 Sep;23(9):1878-1891. (IF = 15.992)  

6. Bao YP*^,#, Han Y^#, Ma J, Wang RJ, Shi L, Wang TY, He J, Yue JL, Shi J, Tang XD, Lu L^*. Cooccurrence and bidirectional prediction of sleep disturbances and depression in older adults: meta-analysis and systematic review.  Neurosci Biobeh  a  v Rev.  2017 Apr;75:257-273. (IF = 8.989)

7. Han Y^#, Luo YX^#, Sun J, Ding ZB, Liu JF, Yan W, Jian M, Xue YX, Shi J, Wang JS^*, Lu L^*. AMPK signaling in the dorsal hippocampus negatively regulates contextual fear memory formation. Neuropsychopharmacology . 2016 Jun;41(7):1849-64. (IF = 7.853)  

8. Zhang RX^#, Han Y^#, Chen C^#, Xu LZ, Li JL, Chen N, Sun CY, Wen CH, Zhu WL, Shi J, Lu L^*. EphB2 in the medial prefrontal cortex regulates vulnerability to stress.  Neuropsychopharmacology . 2016 Sep;41(10):2541-56. (IF = 7.853)

9. Liao F, Wang HX, Dao YK, Yuan K, Lu JZ, Shi J, Han Y^*, Dong SW^*, Lu L^*. Synthesis and biological evaluation of a lipopeptide-based methamphetamine vaccine.  Chin Chem Lett . April 2021, 32(4): 1577-1581. (IF = 6.779)

10. Han Y, Yuan K, Wang Z, Liu WJ, Lu ZA, Liu L, Shi L, Yan W, Yuan JL, Li JL, Shi J, Liu ZC, Wang GH, Kosten T, Bao YP*, Lu L*. Neuropsychiatric manifestations of COVID-19, potential neurotropic mechanisms, and therapeutic interventions.  Transl Psychiatry . 2021 Sep 30;11(1):499.  (IF = 6.222)

11. Han Y, Yan W, Zheng YB, Khan MZ, Yuan K, Lu L*. The rising crisis of illicit fentanyl use, overdose, and potential therapeutic strategies.  Transl Psychiatry . 2019 Nov 11;9(1):282. (IF = 6.222)

12. Deng JH^#, Shi L^#, Yuan K^#, Yao P, Chen SJ, Que JY, Gong YM, Bao YP, Shi J, Han Y^*, Sun HQ^*, Lu L^*. Propranolol-induced inhibition of unconditioned stimulus-reactivated fear memory prevents the return of fear in humans.  Transl Psychiatry . 2020 Oct 13;10(1):345.  (IF = 6.222)

13. Yu Z^#, Chen N^#, Hu D, Chen W, Yuan Y, Meng S, Zhang W, Lu L, Han Y^*, Shi J^*. Decreased density of perineuronal net in prelimbic cortex is linked to depressive-like behavior in young-aged rats.  Front Mol Neurosci . 2020 Jan 28;13:4. (IF = 5.639)

14. Guo H^#, Yuan K^#, Zhang Z, Xue Y, Yan W, Meng S, Zhu W, Wu P, Bao Y, Shi J, Zhang W^*, Lu L^*, Han Y^*. Pi4KIIα regulates unconditioned stimulus-retrieval-induced fear memory reconsolidation through endosomal trafficking of AMPA receptors.  iScience . 2020 Mar 27;23(3):100895.  (IF = 5.458)

Han Y^#, Yuan K^#, Zheng YB, Lu L*. Orexin receptor antagonists as emerging treatments for psychiatric disorders.  Neurosci Bull  .  2020 Apr;36(4):432-448. (IF =" 5.203)