薛言学，北京大学中国药物依赖性研究所副研究员，博士生导师

国家自然科学基金优秀青年基金获得者

 

联系方式

办公地址：北京大学中国药物依赖性研究所

电话：01082802470-520

Email：yanxuexue@bjmu.edu.cn

 

简介

北京大学中国药物依赖性研究所重点室副主任，国家自然科学学基金委优秀青年基金获得者，入选国家重大人才工程青年项目、北京大学博雅青年学者和北脑青年学者。担任中国毒理学会药物依赖性专业委员会青委会主任委员、中国药物滥用防治协会成瘾与脑科学分会副主任委员、中国神经科学会应激神经生物学分会委员等。主要从事情绪记忆及相关精神障碍的神经生物学和临床心理学研究，发表SCI期刊发表论文40余篇，总引用2700余次，其中以第一作者或者通讯作者在 Science 、 JAMA Psychiatry 、 Molecular Psychiatry 、 Nature Communications 、 Biological Psychiatry 、 Neuropsychopharmacology 、 The Journal of Neuroscience 等SCI期刊发表论文20余篇，单篇最高引用470余次，研究发现相继被Science、JAMA Psychiatry等杂志专评。

 

主要研究兴趣和方向

     1. 记忆的分子和环路研究：在动物模型和动物行为学基础上，综合分子生物学、光遗传学、在体超微型显微成像、记忆痕迹标记等技术手段，探索情绪记忆及相关疾病（成瘾、创伤后应激障碍）的分子及环路机制。　　

2. 情绪解码和调控研究：采用人体心理学研究范式，综合人体脑深部电极记录和刺激、机器学习、闭环神经调控等技术，理解情绪（如同情心、抑郁、焦虑、恐惧等）的神经编码机制，发展新的心理学和物理学干预手段。

3. 精神疾病干预策略研究：以精神疾病人群（成瘾、抑郁症患者等）为研究对象，通过随机对照的临床试验，实现药理学、心理学和物理学干预策略的临床转化应用。

代表性论著

1. Han Y, Sun CY, Meng SQ, Tabarak S, Yuan K, Cao L, Yan W, Xu LZ, Deng JH, Zhu WL, Li JL, Lu L*, Xue YX*, Shi J*. Systemic immunization with altered myelin basic protein peptide produces sustained antidepressant-like effects. Mol Psychiatry. 2020，25(6):1260-1274. IF: 13.204

2. Huang X, Chen YY , Shen Y , Cao X, Li A , Liu Q , Li Z , Zhang LB ,Dai W , Tan T , O Arias-Carrion*, Xue YX*, Su H* and Yuan TF* . Methamphetamine abuse impairs motor cortical plasticity and Function. Mol Psychiatry. 2017, 22(9):1274-1281. IF: 13.204

3. Xue YX, Chen YY, Zhang LB, Zhang LQ, Huang GD, Sun SC, Deng JH, Luo YX, Bao YP, Wu P, Han Y, Hope BT, Shaham Y, Shi J, Lu L. Selective inhibition of amygdala neuronal ensembles encoding nicotine-associated memories inhibits nicotine preference and relapse. Biol Psychiatry. 2017 [Epub ahead of print]. IF: 11.412

4. Xue YX^#, Deng JH^#, Chen YY, Zhang LB, Wu P, Huang GD, Luo YX, Bao YP, Wang YM, Shaham Y, Shi J, Lu L. Effect of selective inhibition of reactivated nicotine-associated memories with propranolol on nicotine craving. JAMA Psychiatry. 2017, 74(3):224-232. IF: 15.307

5. Zhang Y^#, Xue Y^#, Meng S, Luo Y, Liang J, Li J, Ai S, Sun C, Shen H, Zhu W, Wu P, Lu L, Shi J. Inhibition of lactate transport erases drug memory and prevents drug relapse. Biol Psychiatry. 2016, 79(11):928-39. IF: 11.412

6. Zhu ZZ^#, Xue YX^#, Han HB, Liu JF, Meng SQ, Chen C, Yang JL, Wu P, Lu L. Overexpression of Protein Kinase Mζ in the Prelimbic Cortex Enhances the Formation of Long-Term Fear Memory. Neuropsychopharmacology. 2015, 40(10):2487. IF: 6.403

7. Luo YX^#, Xue YX^#, Liu JF, Shi HS, Jian M, Han Y, Zhu WL, Bao YP, Wu P, Ding ZB, Shen HW, Shi J, Shaham Y, Lu L.A novel UCS memory retrieval-extinction procedure to inhibit relapse to drug seeking. Nat Commun. 2015, 6:7675. IF: 11.329

8. Liu J, Zhao L, Xue Y, Shi J, Suo L, Luo Y, Chai B, Yang C, Fang Q, Zhang Y, Bao Y, Pickens CL, Lu L. An unconditioned stimulus retrieval extinction procedure to prevent the return of fear memory. Biol Psychiatry. 2014, 76(11):895-901. IF: 10.255

9. Xue YX^#, Xue LF^#, Liu JF, He J, Deng JH, Sun SC, Han HB, Luo YX, Xu LZ, Wu P, Lu L. Depletion of perineuronal nets in the amygdala to enhance the erasure of drug memories. J Neurosci. 2014 May 7;34(19):6647-58. IF: 6.344

10. Chai N^#, Liu JF^#, Xue YX^#, Yang C, Yan W, Wang HM, Luo YX, Shi HS, Wang JS, Bao YP, Meng SQ, Ding ZB, Wang XY, Lu L. Delayed noradrenergic activation in the dorsal hippocampus promotes the long-term persistence of extinguished fear. Neuropsychopharmacology. 2014, 39(8):1933-45. IF: 7.048

11. Ren ZY^#, Liu MM^#, Xue YX^#, Ding ZB, Xue LF, Zhai SD, Lu L.A critical role for protein degradation in the nucleus accumbens core in cocaine reward memory. Neuropsychopharmacology. 2013, 38(5):778-90. IF: 7.833

12. Xue YX^#, Luo YX^#, Wu P^#, Shi HS, Xue LF, Chen C, Zhu WL, Ding ZB, Bao YP, Shi J, Epstein DH, Shaham Y, Lu L.A memory retrieval-extinction procedure to prevent drug craving and relapse. Science. 2012, 336(6078):241-5. IF: 31.02

13. He YY^#, Xue YX^#, Wang JS, Fang Q, Liu JF, Xue LF, Lu L. PKMζ maintains drug reward and aversion memory in the basolateral amygdala and extinction memory in the infralimbic cortex. Neuropsychopharmacology. 2011, 36(10):1972-81. IF: 7.991

14. Li FQ^#, Xue YX^#, Wang JS, Fang Q, Li YQ, Zhu WL, He YY, Liu JF, Xue LF, Shaham Y, Lu L. Basolateral amygdala cdk5 activity mediates consolidation and reconsolidation of memories for cocaine cues. J Neurosci. 2010, 30(31):10351-9. IF: 7.271