张宁 博士

教授，博士生导师

Email：zhangning@bjmu.edu.cn

个人简介：

张宁，男，教授，国家“万人计划”入选者、国家杰出青年科学基金获得者、科技部中青年科技创新领军人才、人事部百千万人才、突出贡献专家教育部新世纪优秀人才，美国李氏基金会杰出成就奖获得者；北京大学第一医院肿瘤转化研究中心常务副主任；中国抗癌协会常务理事、副秘书长，中国抗癌协会期刊出版专业委员会主任委员，纳米肿瘤学专业委员会前任主任委员；中国老年学和老年医学学会转化医学分委会主任委员；《Cancer Biology & Medicine》常务副主编，《Medical Review》副主编。

研究方向与领域：

张宁教授长期从事生物医学研究，围绕肝癌这一关键临床难题，从分子遗传学、细胞生物学、药物筛选、纳米技术等多个侧面入手展开转化应用研究，取得了一系列科研成果。张宁教授近五年在Cancer Cell、Gastroenterology、Nature Communications等国际期刊中发表SCI文章44篇，荣获细胞出版社（Cell Press）2019中国年度论文。同时，张宁教授的研究工作获得国家基金委、科技部等多项基金的支持。

近5年主要代表作：

1. Lin Guo#, Xianfu Yi#, Lu Chen#, Ti Zhang#, Hua Guo, Ziye Chen, Jinghui Cheng, Qi Cao, Hengkang Liu, Chunyu Hou, Lisha Qi, Zhiyan Zhu, Yucun Liu, Ruirui Kong, Chong Zhang, Xiaohua Zhou, Zemin Zhang, Tianqiang Song, Ruidong Xue*, Ning Zhang*. Single cell DNA sequencing reveals punctuated and gradual clonal evolution in hepatocellular carcinoma. Gastroenterology. 2021 Sep 2;

2. Jie Zhu#, Jingxiang Wang#, Xin Wang#, Mingjing Gao#, Bingbing Guo#, Miaomiao Gao, Jiarui Liu, Yanqiu Yu, Liang Wang, Weikaixin Kong, Yongpan An, Zurui Liu, Xinpei Sun, Zhuo Huang, Hong Zhou*, Ning Zhang*, Ruimao Zheng* & Zhengwei Xie*. Prediction of drug efficacy from transcriptional profiles with deep learning. Nature Biotechnology. 2021 Jun 17 ;  

3. Chunqing Wang#, Yongmei Li# , Shuai Yan#, Hao Wang, Xianfeng Shao, Mingming Xiao, Baicai Yang, Guoxuan Qin, Ruirui Kong, Ruibing Chen*, Ning Zhang*. Interactome Analysis Reveals That lncRNA HULC Promotes Aerobic Glycolysis Through LDHA and PKM2. Nature Communications. 2020 Jun 22; 11(1):3162.  

4. Ruidong Xue#, Lu Chen#, Chong Zhang#, Masashi Fujita#, Ruoyan Li, Shu-Mei Yan, Choon Kiat Ong, Xiwen Liao, Qiang Gao, Shota Sasagawa, Yanmeng Li, Jincheng Wang, Hua Guo, Qi-Tao Huang, Qian Zhong, Jing Tan, Lisha Qi, Wenchen Gong, Zhixian Hong, Meng Li, Jingmin Zhao, Tao Peng, Yinying Lu, Kiat Hon Tony Lim, Arnoud Boot, Atushi Ohno, Kazuaki Chayama, Zemin Zhang, Steve George Rozen, Bin Tean Teh, Xin Wei Wang, Hidewaki Nakagawa*, Mu-Sheng Zeng*, Fan Bai*, Ning Zhang*. Genomic and transcriptomic profiling of combined hepatocellular and intrahepatic cholangiocarcinoma reveals distinct molecular subtypes. Cancer Cell. 2019 Jun 10;35(6):932-947.e8.  

5. Ping Zhou#, Jiaqi Qin#, Ce Zhou, Guoyun Wan, Yuanyuan Liu, Mingming Zhang, Xiaoying Yang, Ning Zhang*, Yinsong Wang*. Multifunctional nanoparticles based on a polymeric copper chelator for combination treatment of metastatic breast cancer. Biomaterials. 2019 Mar;195:86-99.  

6. Yun Liu, Xinran Zhang, Baicai Yang, Hao Zhuang, Hua Guo, Wen Wei, Yuan Li, Ruibing Chen, Yongmei Li*, Ning Zhang*. Demethylation-induced overexpression of Shc3 drives c-Raf-independent activation of MEK/ERK in HCC. Cancer Research. 2018 May 1;78(9):2219-2232.

7. Renwei Jing, Xiaoli Zhou, Jingwen Zhao, Yushuang Wei, Bingfeng Zuo, Abin You, Quan Rao, Xianjun Gao, Rong Yang, Lu Chen, Zhen Lu, Qibing Zhou, Ning Zhang*, Haifang Yin*. Fluorescent peptide highlights micronodules in murine hepatocellular carcinoma models and human in vitro. Hepatology. 2018 Oct;68(4):1391-1411.  

8. Ruibing Chen#, Yun Liu#, Hao Zhuang#, Baicai Yang, Kaiwen Hei, Mingming Xiao, Chunyu Hou, Huajun Gao, Xinran Zhang, Chenxi Jia, Lingjun Li, Yongmei Li*, Ning Zhang*. Quantitative proteomics reveals that long non-coding RNA MALAT1 interacts with DBC1 to regulate p53 acetylation. Nucleic Acids Research. 2017 Sep 29;45(17):9947-9959.  

9. Yan Gao#, Xiaohui Ni#, Hua Guo#, Zhe Su#, Yi Ba#, zhongsheng Tong, Zhi Guo, Xin Yao, Xixi Chen, Jian Yin, Zhao Yan, Lin Guo, Ying Liu, Fan Bai*, X. Sunney Xie*, Ning Zhang*. Single-cell sequencing deciphers a convergent evolution of copy number alterations from primary to circulating tumour cells. Genome Research. 2017 Aug;27(8):1312-1322.