郑 铭

　　联系电话：82801403

　　Email: zhengm@pku.edu.cn

　　1993年获西安医科大学医学学士学位，1999年-2001年作为首届美国国立卫生研究院（NIH）联合培养博士研究生，在NIH从事心肌细胞肾上腺素受体信号转导研究，2001年获北京大学医学博士学位。承担多项国家重点基础研究发展计划项目课题（973）及国家自然科学基金项目。

　　目前主要研究兴趣为心血管系统线粒体质量控制及其病理生理意义，尤其是线粒体融合/分裂、线粒体ROS信号、线粒体自噬、线粒体通讯与功能网络在心肌中的作用及作用机制。主要研究方向包括线粒体功能网络调控机制与心肌疾病，以及心肌线粒体自噬机制。

　　近年代表论文：

　　1.Huang X, Sun L, Ji S, Zhao T, Zhang W, Xu J, Zhang J, Wang Y, Wang X, Franzini-Armstrong C, Zheng M*, Cheng H.Kissing and nanotunneling mediate intermitochondrial communication in the heart. Proc Natl Acad Sci U S A. 2013; 110(8):2846-2851. (*correspondence author)

　　2.Zhao T, Huang X, Han L, Wang X, ChengH, Zhao Y, Chen Q, Chen J, Cheng H, Xiao R, Zheng M*. Central Role of Mitofusin 2 in Autophagosome-Lysosome Fusion in Cardiomyocytes. J Biol Chem . 2012; 287(28):23615-25   (*correspondence author)

　　3.Ma Q, Fang H, Shang W, Liu L, Xu Z, Ye T, Wang X, Zheng M*, Chen Q, Cheng H. Superoxide flashes: early mitochondrial signals for oxidative stress-induced apoptosis. J Biol Chem . 2011; 286:27573-81(*correspondence author) 

　　4.Cheng H*, Zheng M*,Peter AK, Kimura K, Li X, Ouyang K, Shen T, Cui L, Frank D, Dalton ND, Gu Y, Frey N, Peterson KL, Evans SM, Knowlton KU, Sheikh F, Chen J. Selective Deletion of Long but not Short Cypher Isoforms Leads to LateOnset Dilated Cardiomyopathy. Hum Mol Genet. 2011; 20:1751-62.  (Co-first author)

　　5.Zheng M, Xiao RP. Role of mitofusin 2 in cardiovascular oxidative injury. J Mol Med . 2010; 88:987-91

　　6.Zheng M, Cheng H, Banerjee I, Chen J. ALP/Enigma PDZ-LIM domain proteins in the heart. J Mol Cell Biol . 2010; 2: 96-102

　　7.Zheng M, Cheng H, Li X, Zhang J, Cui L, Ouyang K, Han L, Zhao T, Gu Y, Dalton ND, Bang ML, Peterson KL, Chen J. Cardiac-specific ablation of cypher leads to a severe form of dilated cardiomyopathy with premature death. Hum Mol Genet . 2009; 18:701-13

　　8.Wang W, Fang H, Groom L, Cheng A, Zhang W, Liu J, Wang X, Li K, Han P, Zheng M, Yin J, Wang W, Mattson MP, Kao JP.Y, Lakatta EG, Sheu S-S, Ouyang K, Chen J, Dirksen RT, Cheng H. Superoxide Flashes in Single Mitochondria. Cell. 2008; 134:279-290

　　9.Shen T*, Zheng M*, Cao C, Chen C, Tang J, Zhang R, Cheng P, Chen KH, Xiao RP. Mitofusin 2 is a major determinant of oxidative stress-mediated heart muscle cell apoptosis.   J.Biol.Chem .2007; 282:23354-61 (*Co-first author)