导师介绍
孙露洋 教授
个人简介
孙露洋，教授，博士生导师，国家自然科学优秀青年基金获得者，入选中组部青年拔尖人才和教育部新世纪人才支持计划。在国家自然科学基金、科技部、北京市重点专项等课题资助下，围绕肿瘤发生、转移和临床耐药，鉴定了多个功能未知的表观因子和转录因子，揭示了组蛋白泛素化、乳酰化等对基因转录的表观调控，在Cell Metabolism, Molecular Cell, Cell Research, Nature Communications, STTT, PNAS, Nucleic Acids Research, Genes & Development, EMBO Reports等杂志发表论文。“乳腺癌发生发展的表观遗传机制”获国家自然科学二等奖（第四完成人）；获中国发明专利授权2项，申请国际专利1项。
研究领域
高等真核生物的基因组DNA，通过缠绕组蛋白八聚体形成核小体，并经折叠形成染色质。染色质具有可塑性，对于需要读取DNA上编码信息的相关生物学过程如基因转录、DNA复制与损伤修复等至关重要。染色质可塑性的失调常伴随着包括肿瘤在内的疾病发生，同时也是疾病干预的重要靶点。
孙露洋课题组致力于肿瘤表观遗传的调控机制。利用基因组及表观组学技术及长读长基因测序结合经典的、分子生物学、细胞生物学以及生物信息学、结构生物学等方法，针对肿瘤发生发展的关键环节，探索组蛋白上化学修饰的催化与识别机制，发现未知的染色体易位及重要的增强子，为肿瘤的精准治疗提供潜在的分子靶点和理论依据。
研究方向
1. 组蛋白化学修饰的动态变化及功能调控
2. 非编码序列的功能鉴定及三维基因组学
实验室成员
主要代表作：（*为第一作者，#为通讯作者）
Ø Lin He, Chunyu Yu, Sen Qin, Enrun Zheng, Xinhua Liu, Yanhua Liu, Shimiao Yu, Yang Liu, Xuelin Dou, Zesen Shang, Yizhou Wang, Yue Wang, Xuehong Zhou, Boning Liu, Yuping Zhong, Zhiqiang Liu, Jin Lu, and Luyang Sun# (2023). The Proteasome Component PSMD14 Drives Myelomagenesis through a Histone Deubiquitinase Activity. Molecular Cell Accepted
Ø Sen Qin*, Yawei Xu*, Shimiao Yu, Wencong Han, Shiheng Fan, Wenxiang Ai, Kenan Zhang, Yizhou Wang, Xuehong Zhou, Qi Shen, Kan Gong#, Luyang Sun#, Zheng Zhang# (2023). ScRNA-seq of Diverse Pheochromocytoma Patients Reveals Distinct Microenvironment Characteristics and Supports an Informative Molecular Classification System. eLife 12:RP87586.
Ø Rui-Yuan Pan*, Lin He*, Jing Zhang, Xinhua Liu, Yajin Liao, Ju Gao, Yang Liao, Yuhan Yan, Qianqian Li, Xuehong Zhou, Jinbo Cheng, Qu Xing, Fangxia Guan, Xinglong Wang, Jie Zhang, Luyang Sun#, Zengqiang Yuan# (2022). Positive Feedback Regulation of Microglial Glucose Metabolism by Histone H4 Lysine 12 Lactylation in Alzheimer’s Disease. Cell Metabolism 34(4):634-648.e6 (ESI Highly Cited Papers)
Highlighted by Yiyun Song# (2022). A vicious cycle. Nature Chemical Biology 18, 434
Highlighted by Yingjun Zhao, and Huaxi Xu# (2022). Microglial lactate metabolism as a potential therapeutic target for Alzheimer’s disease. Molecular Neurodegeneration 17, 36
Ø Xujun Liu*, Wenzhe Si*, Lin He, Jianguo Yang, Yani Peng, Jie Ren, Xiaoping Liu, Tong Jin, Huajing Yu, Zihan Zhang, Xiao Cheng, Wenting Zhang, Lu Xia, Yunchao Huang, Yue Wang, Shumeng Liu, Lin Shan, Yu Zhang, Xiaohan Yang, Haixia Li, Jing Liang, Luyang Sun# and Yongfeng Shang# (2021). The Existence of a Nonclassical TCA Cycle in the Nucleus that Wires the Metabolic-Epigenetic Circuitry. Signal Transduction and Targeted Therapy 6(1):375
Ø Lin He*, Ruorong Yan*, Ziran Yang, Yue Zhang, Xinhua Liu, Jianguo Yang, Xujun Liu, Xiaoping Liu, Lu Xia, Yue Wang, Jiajing Wu, Xiaodi Wu, Lin Shan, Xiaohan Yang, Jing Liang, Yongfeng Shang, and Luyang Sun# (2021). SCFJFK Is Functionally Linked to Obesity and Metabolic Syndrome. EMBO Reports 22(7):e52036
Ø Xia Ting, Lu Xia, Jianguo Yang, Lin He, Wenzhe Si, Yongfeng Shang, and Luyang Sun# (2019). USP11 Acts as a Histone Deubiquitinase Functioning in Chromatin Reorganization during DNA Repair. Nucleic Acids Research 47(18):9721-9740 (Recommended by F1000)
Recommended by F1000: By Prof. Vitaly Citovsky and Prof. Ido Keren. https://connect.h1.co/article/736581402
Ø Lin He, Xinhua Liu, Jianguo Yang, Wanjin Li, Shumeng Liu, Xujun Liu, Ziran Yang, Jie Ren, Yue Wang, Lin Shan,Chengjian Guan, Fei Pei, Liandi Lei, Yu Zhang, Xia Yi, Xiaohan Yang, Jing Liang, Rong Liu, Luyang Sun# and Yongfeng Shang# (2018). Imbalance of the reciprocally inhibitory loop between theubiquitin-specific protease USP43 and EGFR/PI3K/AKT drives breast carcinogenesis. Cell Research 28(9):934-951
Ø Xujun Liu, Wenzhe Si, Xinhua Liu, Lin He, Jie Ren, Ziran Yang, Jianguo Yang, Wanjin Li, Shumeng Liu, Fei Pei, Xiaohan Yang, Luyang Sun# (2017). JMJD6 Promotes Melanoma Carcinogenesis through Regulation of the Alternative Splicing of PAK1, a Key MAPK Signaling Component. Molecular Cancer 2017 16:175
Ø Lifang Li, Xinhua Liu, Lin He, Jianguo Yang, Fei Pei, Wanjin Li, Shumeng Liu, Zhe Chen, Guojia Xie, Bosen Xu, Xia Ting, Zihan Zhang, Tong Jin, Xujun Liu, Wenting Zhang, Shuai Yuan, Ziran Yang, Chongyang Wu, Yu Zhang, Xiaohan Yang, Xia Yi, Jing Liang, Yongfeng Shang, and Luyang Sun# (2017). ZNF516 suppresses EGFR by targeting the CtBP/LSD1/CoREST complex to chromatin. Nature Communications 8(1):691
Ø Ruorong Yan, Lin He, Zhongwu Li, Xiao Han, Jing Liang, Wenzhe Si, Zhe Chen, Lei Li, Guojia Xie, Wanjin Li, Peiyan Wang, Liandi Lei, Hongquan Zhang, Fei Pei, Dengfeng Cao, Luyang Sun#, and Yongfeng Shang# (2015). SCF(JFK) is a bona fide E3 ligase for ING4 and a potent promoter of the angiogenesis and metastasis of breast cancer. Genes &Development 29(6):672-85
Ø Feng Wang, Lin He, Peiwei Huangyang, Jing Liang, Wenzhe Si, Ruorong Yan, Xiao Han, Shumeng Liu, Bin Gui, Wanjin Li, Di Miao, Chao Jing, Zhihua Liu, Fei Pei, Luyang Sun#, and Yongfeng Shang# (2014). JMJD6 Promotes Colon Carcinogenesis through Negative Regulation of p53 by Hydroxylation. PLOS Biology 12(3):e1001819 (Recommended as Editor’s Picks)
Ø Na Yu, Peiwei Huangyang, Xiaohan Yang, Xiao Han, Ruorong Yan, Hongti Jia, Yongfeng Shang, and Luyang Sun# (2013). MicroRNA-7 Suppresses EMT and Invasion of Breast Cancer Cells and Sensitizes Cells to DNA Damages by Targeting Lysine Methyltransferase SET8. Journal of Biological Chemistry 288(27): 19633-42
Ø Lei Shi*, Luyang Sun*, Qian Li, Jing Liang, Wenhua Yu, Xia Yi, Xiaohan Yang, Yanyan Li, Xiao Han, Yu Zhang, Chenghao Xuan, Zhi Yao, Yongfeng Shang (2011). JMJD2B Coordinates H3K4/H3K9 Methylation and Promotes Hormonally Responsive Breast Carcinogenesis. PNAS 108(18):7541-6
Ø Luyang Sun, Lei Shi, Feng Wang, Peiwei Huangyang, Wenzhe Si, Jie Yang, Zhi Yao, and Yongfeng Shang (2011). Substrate Phosphorylation and Feedback Regulation in JFK-promoted p53 Destabilization. Journal of Biological Chemistry 286(6):4226-35
Ø Luyang Sun*, Lei Shi*, Wenqian Li, Wenhua Yu, Jing Liang, Hua Zhang, Xiaohan Yang, Yan Wang, Ruifang Li, Xingrong Yao, Xia Yi, and Yongfeng Shang (2009). JFK, a Kelch Domain-containing F-box Protein, Links the SCF Complex to p53 Regulation. PNAS 106(25): 10195-10200 (Recommended by F1000)
Recommended by F1000: By Prof. Anindya Dutta. https://connect.h1.co/article/1162802
联系方式
Email: Luyang_sun@hsc.pku.edu.cn