贾 兵

副研究员、博士生导师（放射医学、中西医结合）

联系方式：Email：jiabing@bjmu.edu.cn

电话：010-82802871

办公室：中心实验楼303A

贾兵副研究员2001年参与组建北京大学医学同位素研究中心，主要在放射性核素分子显像药物及肿瘤放射靶向治疗方面开展研究工作。作为课题负责人先后主持5项国自然及1项北京市自然基金；作为子课题负责人承担和参与科技部“973”、“重大新药创制课题”、国自然“国家重点科研仪器研制项目”等科研课题各1项。获授权国家发明专利16项，在国内外学术刊物公开发表论文80余篇，其中SCI论文72篇。作为第2完成人参与开发的新型肿瘤特异性显像剂^99mTc-3PRGD2从2013年开始进行化药1类新药的申报，目前已经完成全部临床实验，正在申请新药证书。

研究方向：放射性药物、肿瘤分子影像及放射靶向治疗

主要学术任职：

中国核学会同位素分会理事北京核学会核医学与分子影像学专业委员会委员

中国生物物理学会分子影像学专业委员会委员

Am J Nucl Med Mol Imaging，Associate Editorial Board Member

近五年代表性论文：

1. Shi L, Chen B, Liu T, Li L, Hu B, Li C, Jia B*, Wang F*. ^99mTc-CD3813: A Nanobody-Based Single Photon Emission Computed Tomography Radiotracer with Clinical Potential for Myeloma Imaging and Evaluation of CD38 Expression.  Mol Pharm . 2022 Jun 13. doi: 10.1021/acs.molpharmaceut.2c00279. Epub ahead of print. PMID: 35696536. (IF: 4.939; Q1, 共同责任作者)

2. Hu B, Liu T, Li L, Shi L, Yao M, Li C, Ma X, Zhu H, Jia B*, Wang F. IgG-Binding Nanobody Capable of Prolonging Nanobody-Based Radiotracer Plasma Half-Life and Enhancing the Efficacy of Tumor-Targeted Radionuclide Therapy.  Bioconjug Chem . 2022 Jun 10. doi: 10.1021/acs.bioconjchem.2c00209. Epub ahead of print. PMID: 35687724. (IF: 4.774; Q1,责任作者)

3. Liu T, Wu Y, Shi L, Li L, Hu B, Wang Y, Gao H, Yu X, Zhang X, Zhao H, Wan Y, Jia B*, Wang F*. Preclinical evaluation of [^99mTc]Tc-labeled anti-EpCAM nanobody for EpCAM receptor expression imaging by immuno-SPECT/CT.  Eur J Nucl Med Mol Imaging . 2022, 49(6):1810-1821.. doi: 10.1007/s00259-021-05670-z. (PMID: 35013776) (IF: 9.236; Q1, 共同责任作者)

4. Zhang X, Chen M, Zhang Y, Hou Y, Wu Y, Yao M, Li L, Shi L, Liu T, Hu B, Zhao H, Li X, Shi J, Jia B*, and Wang F. Monoclonal-Antibody-Templated Gold Nanoclusters for HER2 Receptors Targeted Fluorescence Imaging.  ACS Appl Bio Mater . 2020, 3, 10, 7061–7066.

5. Gao S^#, Jia B^#, Feng G^#, Dong C^#, Du H, Bai L, Zhong Q, Ma Q, Zeng M, Wang F*. First-in-human Pilot Study of an Integrin α6-targeted Radiotracer for SPECT Imaging of Breast Cancer.  Signal Transduct Target Ther . 2020, 5(1):147. (IF: 13.493; Q1, 共同第一作者)

6. Yao M, Ma X, Zhang X, Shi L, Liu T, Liang X, Zhao H, Li X, Li L, Gao H, Jia B*, Wang F*. Lectin-mediated pH-sensitive Doxorubicin Prodrug for Pre-targeted Chemotherapy of Colorectal Cancer with Enhanced Efficacy and Reduced Side Effects.  Theranostics . 2019, 9(3):747-760. (IF: 8.537; Q1, 共同责任作者)

7. Jia B^#, Zhang X^#, Wang B, Chen M, Lv F, Wang S*, Wang F*. Dual-Modal Probe Based on Polythiophene Derivative for Pre- and Intraoperative Mapping of Lymph Nodes by SPECT/Optical Imaging.  ACS Appl Mater Interfaces . 2018, 10(7):6646-6651. (IF: 7.504; Q1, 共同第一作者)

8. Zhang X, Yao M, Chen M, Li L, Dong C, Hou Y, Zhao H, Jia B^*, Wang F*. Hyaluronic Acid-Coated Silver Nanoparticles As a Nanoplatform for in Vivo Imaging Applications.  ACS Appl Mater Interfaces . 2016, 8(39):25650-25653. (IF: 7.504; Q1, 共同责任作者)

9. Dong C, Yang S, Shi J, Zhao H, Zhong L, Liu Z, Jia B*, Wang F. SPECT/NIRF Dual Modality Imaging for Detection of Intraperitoneal Colon Tumor with an Avidin/Biotin Pretargeting System.  Sci Rep . 2016, 6:18905. (IF: 4.122; Q1, 责任作者)